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. 2020 Jun 8;11(6):437. doi: 10.1038/s41419-020-2635-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Investigation for the potential miRNAs of circSLC25A16 reveals that circSLC25A16 targets miR-488-3p as a classic miRNA sponge. Wild type and mutant sequences were constructed for the luciferase reporter assay. b RNA-FISH analysis indicated the cytoplasmic segment or nucleus segment of circSLC25A16 in A549 cells. c Subcellular location analysis by RT-PCR found the location of circSLC25A16 in cytoplasm or nucleus. d Luciferase reporter assay presented the luciferase activity with the miR-488-3p mimics or control and circSLC25A16 mutant or wild type. e RT-PCR indicated the miR-488-3p expression in A549 cells using the circSLC25A16 knockdown and overexpression transfection. **p < 0.01.