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. 2020 Jun 8;10:9164. doi: 10.1038/s41598-020-66009-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of capsaicinoids on γ-secretase. (a) Levels of presenilin 1 (PS1) protein after treatment with capsaicin, natural compound and DHC on SH-SY5Y cells analyzed by WB (n ≥ 5). (b) Gene expression analysis of γ-secretase complex components (APH1a, NCSTN, PSEN1, PSEN2, PSENEN) in capsaicinoid treated SH-SY5Y cells (n = 4). (c) γ-secretase activity in living cells (n ≥ 9) and in isolated membranes (n = 3) of SH-SY5Y wt cells after capsaicin incubation. (d) Protein levels of PS1 in rafts and non-rafts after capsaicin incubation (n = 3). Representative, immunodetected PS1 signals are shown on the right. (e) γ-secretase activity in raft and non-raft fractions after capsaicin treatment (n = 3). Error bars represent the standard error of the mean. Asterisks show the statistical significance calculated by unpaired Student’s t test or ANOVA (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001).