Fig. 1. Flowcharts to show use of ER and PgR categories and on-NeoET Ki67 for directing postmenopausal patients with primary ER + HER2-breast cancer towards NeoET or surgery/neoadjuvant chemotherapy based on Allred scores or based on % cells positive.

Allred scores are created by summing two separate scores: (the overall intensity of stained cells, none = 0, weak = 1, intermediate = 2, strong = 3) + (percentage of cells staining positive none = 0, <1% = 1, 1–10% = 2, 11–33% = 3, 34–66% = 4, ≥67% = 5).