Table 3.
Summary of Reported Outcomes in Randomized Controlled Trials Assessing NSAIDs Versus Antibiotics for Women with Uncomplicated UTIs
| Patients, n | Patients with symptom resolution by day 3 or 4, n (%) | Mean of post-treatment total symptom score on day 5* | Women receiving antibiotics for any reason during study period, n (%) | Patients with pyelonephritis during the study period, n (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Study, year | NSAID | Antibiotic | NSAID | Antibiotic | Risk difference (95% CI)† | NSAID | Antibiotic | p value | NSAID | Antibiotic | Risk difference (95% CI)‡ | NSAID | Antibiotic | Risk difference (95% CI)§ |
| Bleidorn et al., 2010 | 40 | 39 | 21 (58)| | 17 (52)| | 9 (− 13 to 31)| | NR | NR | NR | NR | NR | NR | NR | NR | NR |
| Gágyor et al., 2015 | 248 | 246 | 91 (39)| | 129 (56)| | 17 (9 to 26)| | NR | NR | NR | 85 (35) | 243 (100) | − 65 (− 71 to − 59) | 5 (2) | 1 (0.4) | 1.7 (− 0.3 to 3.6) |
| Jamil et al., 2016 | 50 | 50 | NR | NR | NR | 1.4 | 1.9 | 0.13 | NR | NR | NR | NR | NR | NR |
| Kronenberg et al., 2017 | 133 | 120 | 72 (54)¶ | 96 (80)¶ | 27 (15 to 38)¶ | NR | NR | NR | 82 (62) | 118 (98) | − 37 (− 46 to − 28) | 6 (5) | 0 (0) | 5 (1 to 8) |
| Vik et al., 2018 | 194 | 189 | 70 (39)| | 131 (74)| | 35 (27 to 43)| | NR | NR | NR | NR | NR | NR | 7 (4) | 0 (0) | 4 (1 to 8) |
UTI, urinary tract infection; NSAID, non-steroidal anti-inflammatory drug; NR, not reported
*Total symptom score is the sum of symptom scores for urinary frequency, urgency, dysuria, and pain
†Positive numbers indicate higher rates of symptom resolution among patients receiving antibiotics compared with those receiving NSAIDS
‡Positive numbers indicate higher rates of antibiotic use in the NSAID group
§Positive numbers indicate higher rates of pyelonephritis in the NSAID group
|Symptom resolution by day 4
¶Symptom resolution by day 3