Table 2.
Predictive power of PCE risk factors in young vs. old.
| Variable | HR represents | Younger than 75 years-old | 75 years-old or older | p value interaction | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted p value | Unadjusted HR (95% CI) |
Univariate c-index | Adjusted p value | Adjusted HR (95% CI) |
Unadjusted p value | Unadjusted HR (95% CI) |
Univariate c-index |
Adjusted p value | Adjusted HR (95% CI) |
|||
| Sex (female) | Female vs. male | < 0.001 | 0.60 (0.52–0.68) | 0.572 | < 0.001 | 0.61 (0.53–0.71) | 0.104 | 0.88 (0.76–1.03) | 0.513 | 0.063 | 0.85 (0.72–1.01) | 0.004 |
| Age | 5 years increase | < 0.001 | 1.52 (1.44–1.60) | 0.680 | 0.001 | 1.45 (1.37–1.53) | < 0.001 | 1.51 (1.36–1.66) | 0.587 | < 0.001 | 1.48 (1.34–1.63) | 0.674 |
| Race |
Black vs. White Other vs. White |
< 0.001 |
0.66 (0.53–0.84) 0.49 (0.38–0.64) |
0.558 | < 0.001 |
0.64 (0.50–0.81) 0.57 (0.44–0.73) |
< 0.001 |
0.69 (0.51–0.94) 0.55 (0.40–0.77) |
0.535 | < 0.001 |
0.65 (0.48–0.89) 0.55 (0.39–0.77) |
0.974 |
| Total cholesterol | 10 units increase | 0.038 | 1.02 (1.00–1.04) | 0.525 | < 0.001 | 1.04 (1.02–1.06) | 0.313 | 1.01 (0.99–1.03) | 0.513 | 0.056 | 1.02 (1.00–1.04) | 0.261 |
| HDL-C |
10 units increase at 40 10 units increase at 60 10 units increase at 80 |
< 0.001 |
0.75 (0.69–0.81) 0.93 (0.87–1.00) 1.05 (0.92–1.19) |
0.588 | < 0.001 |
0.79 (0.73–0.87) 0.97 (0.91–1.04) 1.05 (0.93–1.19) |
0.137 |
0.99 (0.89–1.11) 0.92 (0.84–1.00) 0.93 (0.79–1.10) |
0.518 | 0.289 |
1.01 (0.90–1.13) 0.92 (0.85–1.00) 0.92 (0.78–1.07) |
0.012 |
| SBP | 10 units increase | < 0.001 | 1.23 (1.19–1.27) | 0.646 | < 0.001 | 1.15 (1.11–1.18) | < 0.001 | 1.12 (1.09–1.16) | 0.577 | < 0.001 | 1.11 (1.08–1.15) | 0.248 |
| BP meds | Yes vs. no | < 0.001 | 1.68 (1.47–1.92) | 0.567 | 0.014 | 1.19 (1.04–1.38) | 0.014 | 1.21 (1.04–1.40) | 0.520 | 0.434 | 1.07 (0.91–1.25) | 0.316 |
| Smoker | Yes vs. no | < 0.001 | 1.84 (1.56–2.18) | 0.546 | < 0.001 | 2.38 (2.00–2.82) | 0.107 | 1.30 (0.95–1.78) | 0.510 | 0.009 | 1.53 (1.11–2.10) | 0.020 |
| Diabetes | Yes vs. no | < 0.001 | 2.27 (1.91–2.69) | 0.554 | < 0.001 | 1.77 (1.48–2.12) | < 0.001 | 1.68 (1.37–2.07) | 0.533 | < 0.001 | 1.83 (1.47–2.26) | 0.795 |
BP, blood pressure; CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; PCE, Pooled Cohort Risk Equations; SBP, systolic blood pressure c-index multivariable models: <75 years old: 0.759, ≥75 years old: 0.646