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. 2020 Jun 2;11:984. doi: 10.3389/fimmu.2020.00984

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Copyright © 2020 Malherbe, Wibmer, Nonyane, Reed, Sather, Spencer, Schuman, Guo, Pandey, Robins, Park, Fuller, Sacha, Moore, Hessell and Haigwood.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epitope targeting of rabbit antibodies after the fourth immunization. (A) Pooled rabbit sera from each group were used to assess responses to linear epitopes contained in the clade C consensus Env peptides (15-mer with 11 aa overlap). Data are presented as absorbance (OD at 450 nm) after subtraction of background from naïve serum. V1V2 binding antibody responses were evaluated with (B) clade B gp70 V1V2 (C) V1V2(ZM53)-2F5K recombinant scaffold proteins. (D) CD4bs-specific binding antibody responses were evaluated with resurfaced gp120 recombinant core protein RSC3. Data in panels (B–D) are presented as mid-point titers. P-values determined by One-Way ANOVA with Kruskal–Wallis test for multiple comparisons. Lines indicate mean with SEM. Color coding for rabbit groups in panel (A) match groups indicated in panels (B–D).