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. 2020 Jun 8;11:2866. doi: 10.1038/s41467-020-16499-9

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© The Author(s) 2020, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — CUL5 (brown circles) residues 30–40, 105–114, 214–229, and 545–551 showed decreased exchange upon CKB binding (magenta circles) to the ASB9 CRL. For all HDX-MS data, at least two biological replicates were analyzed each with three technical replicates. Data are represented as mean values ± SEM of three technical replicates due to processing software limitations, however the LEAP robot provides highly reproducible data for biological replicates and therefore error bars are sometimes within the symbols. Source data for the HDX-MS results are provided as Source Data files.