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. 2020 Jun 8;11:2866. doi: 10.1038/s41467-020-16499-9

Fig. 7. The predicted allosteric path from substrate, CKB, through the CRL.

Fig. 7

CKB binding communicates through the substrate receptor, ASB9 which behaves as a rigid rod, through ELOB/C which behaves as a hinge, and finally through CUL5, which also behaves as a rigid rod. Both ASB9 and CUL5 appear to move as rigid bodies in the allosteric network. The network terminates in RBX2, which appears to be connected to CUL5 by a flexible (very high amide exchange) tether.