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. 2020 Jun 8;11:2866. doi: 10.1038/s41467-020-16499-9

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© The Author(s) 2020, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — CKB binding communicates through the substrate receptor, ASB9 which behaves as a rigid rod, through ELOB/C which behaves as a hinge, and finally through CUL5, which also behaves as a rigid rod. Both ASB9 and CUL5 appear to move as rigid bodies in the allosteric network. The network terminates in RBX2, which appears to be connected to CUL5 by a flexible (very high amide exchange) tether.