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. 2020 Jun 8;10:9239. doi: 10.1038/s41598-020-66197-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The heat map of methylation levels (b-values) of CpG dinucleotides in luminal B breast cancer samples with different response to neoadjuvant chemotherapy (NACT) identified in this study using XmaI-RRBS method. The red bars and green bars represent hypermethylation CpG sites and hypomethylation CpG sites, respectively. Data are presented in a matrix format: each row represents a CpG dinucleotide differential methylation of which marks the differences in the responses of BC tumors to NACT, and each column, a tumor sample. Patients’ age, tumor size (T) and lymph node status (N), response to NACT are indicated as colored rectangles.