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. 2020 Jun 2;11:925. doi: 10.3389/fimmu.2020.00925

Figure 2.

Figure 2

VCAM-1 and ICAM-1 expression by RASFs after stimulation with selected adipokines and therapeutics. Results were compared to non-stimulated controls. (A) mRNA expression of VCAM-1 by RASFs after stimulation with adiponectin (n = 5), visfatin (n = 10), resistin (n = 10), TNF-α (n = 9), or therapeutics (n = 8 each). Adipokines and methotrexate did not have any effect on expression of VCAM-1, whereas TNF-α upregulated expression of VCAM-1 [16.4-fold (rhombus), 95% CI = 4.9–55], but not significantly. Dexamethasone (−5.09-fold, 95% CI = 0.095–0.408) and prednisolone [−3.2-fold (rhombus), 95% CI = 0.14–0.717] downregulated expression of VCAM-1. (B) mRNA expression of ICAM-1 by RASFs after stimulation with adiponectin (n = 4), visfatin (n = 7), resistin (n = 7), TNF-α (n = 5), and therapeutics (each n = 5). Adipokines and therapeutics did not have any effect on expression of ICAM-1. Tumor necrosis factor α significantly upregulated expression of ICAM-1 [20.4-fold (rhombus), 95% CI = 6.07–68].