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. 2020 Jun 2;11:925. doi: 10.3389/fimmu.2020.00925

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Copyright © 2020 Hasseli, Frommer, Schwarz, Hülser, Schreiyäck, Arnold, Diller, Tarner, Lange, Pons-Kühnemann, Schönburg, Rehart, Müller-Ladner and Neumann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rheumatoid arthritis synovial fibroblast adhesion to E-selectin and HUVEC under flow conditions. A flow adhesion assay was used to evaluate the effect of the selected adipokines visfatin, resistin, TNF-α (A & C) and therapeutics prednisolone, dexamethasone and methotrexate (B & D) to E-selectin and HUVEC (each n = 6). Unstimulated RASF served as control. The percentage of change in adherent RASF compared to unstimulated RASF was calculated. (A) Visfatin increased adhesion to E-Selectin in most of the samples (NS). (B) Stimulation with dexamethasone significantly (p = 0.043) decreased adhesion to E-selectin coated capillaries (8.4 ml/h: −40.9%, 30.5 ml/h: −40%, 60.5 ml/h: −29.7%). (C) Significant increase (p = 0.002) of adhesion to HUVEC could be observed after stimulation with visfatin (18.4 ml/h: 75.2%, 30.5 ml/h: 37.9%, 60.5 ml/h: 49.8%). (D) Stimulation with therapeutics did not reach any significant change in adhesion.