FIGURE 1.

Diagram showing , over 24 h, the peak of cytokines and immune responses involved in the cytokine release storm (CRS) of COVID‐19. Peak detrimental inflammatory mediators (red) and beneficial adaptive immune response against viral infections (green) are shown during a 24‐h time period. The dotted line and the red clock indicate the period between 4:00 p.m. and midnight in which the detrimental effects of CRS outweighs the beneficial effect of the adaptive immune response. This period of time could be the ideal target for anti‐inflammatory treatments. On the other hand, the green clocks indicate the periods of anti‐viral activity of the immune system; these are the periods in which anti‐inflammatory therapy should be avoided