Table 1.

Chronologic data analysis from a 35 years literature review period on IORT for Pancreatic cancer after surgical resection (31 articles, 1.435 patients).

Treatment Characteristics	1981–1989	1990–1999	2000–2009	2010–2018
Resected
▪ #Studies	5	12	8	6
▪ #Patients	46	257	611	521
References	[18], [19], [20], [21], [28]	[14], [22], [23], [24], [29], [30], [31], [32], [33], [34], [35], [36]	[25], [26], [37], [38], [39], [41], [42], [43]	[12], [15], [16], [17], [27], [44]
IORT
▪ Dose range (Gy)	10–40	10–30	7.5–25	10–30
▪ Mean dose (Gy)	25	15	15	15
▪ Electron beam	100%	100%	100%	75%
▪ 250 kV	–	–	–	25%
EBRT delivered
> 50% patients	75%	39%	75%	50%
Adjuvant CT
> 50% pts	0%	70%	100%	60%
Median Survival
▪ Range (months)	5–12.6	10–19	9–28	19–35
▪ Mean (months)	9.5	15	15	23

IORT: IntraOperative Radiation Therapy; EBRT: external beam radiotherapy; CT: chemotherapy; Gy: Gray; kV: kilovoltage