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Failure of metformin to prevent podocytopathy in Asah1fl/fl/PodoCre mice. A: Summarized data of blood glucose in different groups of mice at 8 weeks B: Summarized data of glucose tolerance in different groups of mice at 8 weeks. C: Urinary albumin (UAlbumin) excretion of WT/WT and Asah1fl/fl/PodoCre mice with treatments of vehicle or metformin hydrochloride. n = 6 to 17 (A); n = 4 to 6 (B); n = 5 (C). ∗P < 0.05 versus WT/WT-vehicle. gbw, gram of body weight.
