Fig. 4.

Transcriptional response of PBMCs to RSV peptide stimulation: A) Principle Component Analysis (PCA) representing each sample upon re-stimulation with DMSO, F, M, N and G, B) Enrichment of transcription factor binding sites in differentially expressed genes upon re-stimulation with F and M peptide. The colors represent –log₁₀(P-value), calculated by hypergeometric test, C) Multivariate enrichment analysis of gene signatures of T cell subtypes performed using Qgen using visit number and GRSS as covariates. The colors blue to red indicate activities ranging from low to high. Stars indicate significance * p < 0.05. The names of the transcription factor binding sites in B and gene signatures of T cell subtypes in C have been modified for ease of understanding. The original names corresponding to those names have been provided in Supplementary Table 2. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)