Fig. 2.

Evaluation of activities of infant RSV gene signatures in RSV-peptide stimulation study: A) Enrichment of T cell associated gene-signatures (y-axis) in 13 RSV response clusters (x-axis) identified using previously published transcriptomic data measuring response to RSV infections in infant PBMCs [22], [23]. Colors represent –log₁₀(p-value) calculated by hypergeometric test, blue represents < 1.3 (non-significant), B) Activities of the 13 clusters upon re-stimulation of PBMCs with RSV-peptides (x-axis) and C) in transcriptomic data obtained from [22], [23] using Qgen where visit number and GRSS are covariates. These previously published studies stratified the subjects into mild (red circles, data from 9 subjects), moderate (green triangles, data from 9 subjects), severe (blue diamonds, data from 8 subjects) and infected (black rectangles, data from 51 subjects). The names of gene signatures of T cell subtypes in A have been modified for ease of understanding. The original names corresponding to those names have been provided in Supplementary Table 2. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)