Table 5.

Predicted drug targets for asiatic acid, guajaverin, aviculerin, and withaferin.

Metab-olites	Drug Targets	Common Name	Uniprot ID	ChEMBL ID	Target Class	Probability
Asiatic Acid	Aldo-keto reductase family 1 member B10	AKR1B10	O60218	CHEMBL5983	Enzyme
	Protein-tyrosine phosphatase 1B	PTPN1	P18031	CHEMBL335	Phosphatase
	11-β-hydroxysteroid dehydrogenase 1	HSD11B1	P28845	CHEMBL4235	Enzyme
	DNA polymerase beta	POLB	P06746	CHEMBL2392	Enzyme
	T-cell protein-tyrosine phosphatase	PTPN2	P17706	CHEMBL3807	Phosphatase
	Phospholipase A2 group 1B	PLA2G1B	P04054	CHEMBL4426	Enzyme
Guajaverin & Aviculerin	Aldose reductase	AKR1B1	P15121	CHEMBL1900	Enzyme
	Carbonic anhydrase II	CA2	P00918	CHEMBL205	Lyase
	Carbonic anhydrase VII	CA7	P43166	CHEMBL2326	Lyase
	Carbonic anhydrase XII	CA12	O43570	CHEMBL3242	Lyase
	Carbonic anhydrase IV	CA4	P22748	CHEMBL3729	Lyase
	NADPH oxidase 4	NOX4	Q9NPH5	CHEMBL1250375	Enzyme
	Adrenergic receptor alpha-2	ADRA2C	P18825	CHEMBL1916	Family A G protein-coupled-receptor
	Acetylcholinesterase	ACHE	P22303	CHEMBL220	Hydrolase
	Quinone reductase 2	NQO2	P16083	CHEMBL3959	Enzyme
	Ribosomal protein S6 kinase alpha 3	RPS6KA3	P51812	CHEMBL2345	Kinase
	Neuromedin-U receptor 2	NMUR2	Q9GZQ4	CHEMBL1075144	Family A G protein-coupled receptor
Withaferin	Protein kinase C alpha	PRKCA	P17252	CHEMBL299	Kinase
	Cyclooxygenase-2	PTGS2	P35354	CHEMBL230	Oxidoreductase
	Isoleucyl-tRNA synthetase	IARS	P41252	CHEMBL3235	Enzyme
	Protein kinase C delta	PRKCD	Q05655	CHEMBL2996	Kinase
	HMG-CoA reductase	HMGCR	P04035	CHEMBL402	Oxidoreductase
	Phosphodiesterase 4D	PDE4D	Q08499	CHEMBL288	Phosphodiesterase
	Telomerase reverse transcriptase	TERT	O14746	CHEMBL2916	Enzyme
	Androgen Receptor	AR	P10275	CHEMBL1871	Nuclear receptor
	Protein kinase C epsilon	PRKCE	Q02156	CHEMBL3582	Kinase
	Proto-oncogene c-JUN	JUN	P05412	CHEMBL4977	Transcription factor
	Protein-tyrosine phosphatase 1B	PTPN1	P18031	CHEMBL335	Phosphatase