Table 3.
Selected hematology analyses of rats in toxicity study
| Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | |
| RBC (× 1012/L) | 7.196 ± 0.090 | 7.225 ± 0.340 | 7.346 ± 0.418 | 7.462 ± 0.430 | 7.276 ± 0.421 | 7.300 ± 0.347 |
| HCT (%) | 39.32 ± 0.740 | 38.98 ± 1.992 | 39.08 ± 0.958 | 38.50 ± 2.253 | 38.90 ± 2.220 | 37.05 ± 0.576 |
| MCV (fL) | 54.64 ± 0.541 | 52.28 ± 0.784 | 53.28 ± 1.767 | 53.34 ± 0.845 | 53.00 ± 0.714 | 53.04 ± 1.681 |
| MCH (pg) | 18.66 ± 0.114 | 18.01 ± 0.470 | 18.10 ± 0.765 | 18.39 ± 0.341 | 17.82 ± 1.043 | 18.51 ± 0.905 |
| MCHC (g/dL) | 34.18 ± 0.523 | 34.42 ± 0.480 | 33.96 ± 0.493 | 34.50 ± 0.245 | 34.48 ± 0.590 | 35.12 ± 0.545 |
| RDW (%) | 17.42 ± 0.444 | 17.87 ± 0.912 | 17.78 ± 0.691 | 17.29 ± 1.152 | 17.30 ± 0.570 | 17.92 ± 0.651 |
| RETIC (K/μL) | 2.86 ± 0.434 | 3.78 ± 0.630 | 2.78 ± 0.691 | 2.93 ± 0.706 | 2.48 ± 0.798 | 2.81 ± 0.802 |
| RETIC | 214.7 ± 35.25 | 270.6 ± 39.98 | 202.2 ± 42.64 | 216.6 ± 49.50 | 162.3 ± 5.118 | 178.0 ± 19.04 |
| WBC (×1012/L) | 7.644 ± 1.668 | 6.932 ± 2.50 | 7.592 ± 2.96 | 7.504 ± 2.121 | 6.440 ± 1.248 | 5.883 ± 2.897 |
| NEU (%) | 13.72 ± 4.217 | 17.50 ± 5.977 | 12.48 ± 2.104 | 15.40 ± 5.918 | 12.10 ± 2.351 | 14.66 ± 2.831 |
| LYM (%) | 75.06 ± 5.697 | 73.91 ± 6.311 | 80.36 ± 4.360 | 79.33 ± 7.194 | 78.88 ± 3.440 | 76.26 ± 2.858 |
| MONO (%) | 5.180 ± 0.832 | 6.800 ± 0.902 | 4.520 ± 1.117 | 5.540 ± 1.169 | 4.540 ± 0.963 | 6.160 ± 1.190 |
| EOS (%) | 0.60 ± 0.123 | 0.80 ± 0.340 | 0.80 ± 0.200 | 0.53 ± 0.200 | 0.62 ± 0.356 | 0.61 ± 0.166 |
| BASO (%) | 0.14 ± 0.114 | 0.25 ± 0.151 | 0.20 ± 0.141 | 0.18 ± 0.140 | 0.16 ± 0.114 | 0.19 ± 0.171 |
| NEU (× 109/L) | 1.024 ± 0.288 | 1.116 ± 0.495 | 0.976 ± 0.153 | 1.011 ± 0.468 | 1.096 ± 0.163 | 1.000 ± 0.096 |
| LYM (× 109/L) | 6.178 ± 1.593 | 4.849 ± 2.150 | 6.158 ± 2.684 | 6.002 ± 2.089 | 5.672 ± 0.854 | 5.398 ± 1.097 |
| MONO (× 109/L) | 0.386 ± 0.042 | 0.455 ± 0.161 | 0.426 ± 0.083 | 0.415 ± 0.120 | 0.406 ± 0.067 | 0.346 ± 0.111 |
| EOS (× 109/L) | 0.046 ± 0.011 | 0.05 ± 0.017 | 0.050 ± 0.029 | 0.037 ± 0.016 | 0.004 ± 0.012 | 0.034 ± 0.013 |
| BASO (× 109/L) | 0.01 ± 0.007 | 0.014 ± 0.010 | 0.001 ± 0.007 | 0.013 ± 0.07 | 0.016 ± 0.009 | 0.016 ± 0.012 |
| PLT (K/μL) | 1001 ± 193.2 | 1107 ± 178.6 | 1032 ± 142.8 | 974.4 ± 121.9 | 1169 ± 74.37 | 1075 ± 45.99 |
| MPV (fL) | 8.50 ± 0.100 | 8.43 ± 0.216 | 8.42 ± 0.148 | 8.63 ± 0.095 | 8.44 ± 0.089 | 8.47 ± 0.206 |
| PDW (fL) | 8.50 ± 0.158 | 8.62 ± 0.148 | 8.46 ± 0.422 | 8.30 ± 0.133 | 8.42 ± 0.303 | 8.71 ± 0.778 |
| PCT (%) | 1.037 ± 0.038 | 0.962 ± 0.137 | 0.870 ± 0.129 | 0.80 ± 0.151 | 0.844 ± 0.167 | 0.88 ± 0.107 |
Note: Measurements are given as the mean ± SD. RBC: Red blood cells; HCT: Hematocritt; MCV: Average red blood cell volume; MCH: Average hemoglobin concentration; RDW: Red blood cell distribution width; RETIC: Reticulocytes; WBC: White blood cells; NEU: Neutrophils; LYM: Lymphocytes; MONO: Monocytes; EOS: Eosinophils; BASO: Basophils; PLT: Platelet; MPV: Mean platelet volume; PDW: Platelet distribution width.