Fig. 1|. Expression of ACE2 and TMPRSS2 across different tissues and its enrichment in nasal epithelial cells.

a, RNA expression of SARS-CoV-2 entry receptor ACE2 (first column), entry-associated protease TMPRSS2 (second column), and their co-expression (third column) from multiple published scRNA-seq datasets. Raw expression values were normalized, log transformed and summarized by published cell clustering where available, or reproduced clustering annotated using marker genes and cell type nomenclature from the respective studies. The size of the dots indicates the proportion of cells in the respective cell type having greater-than-zero expression of ACE2 (first column), TMPRSS2 (second column) or both (third column), while the colour indicates the mean expression of ACE2 (first and third columns) or TMPRSS2 (second column). b, Schematic illustration depicts the major anatomical regions in the human respiratory tree demonstrated in this study: nasal, lower airway, and lung parenchyma (left panel). Expression of ACE2 is from airway epithelial cell datasets: Vieira Braga, Kar et al. 2019 (middle panel) and Deprez et al. 2019 (right panel). The datasets were retrieved from existing sources, and the cell clustering and nomenclature were retained based on the respective studies. For gene expression results in the dot plots: the dot size represents the proportion of cells within the respective cell type expressing the gene and the dot color represents the average gene expression level within the particular cell type.