Table 1.
PSP (n = 76) | PSP-RS (n = 53) | PSP-P (n = 16) | p value (PSP-RS vs. PSP-P) | |
---|---|---|---|---|
Age (years) | 62.04 ± 7.10 | 62.19 ± 7.86 | 61.19 ± 5.07 | 0.63 |
Gender (M:W) | 53:23 | 35:18 | 13:03 | 0.35 |
Age of onset (years) | 59.55 ± 7.10 | 60.17 ± 7.65 | 56.81 ± 5.52 | 0.10 |
Duration of illness (years) | 2.68 ± 2.10 | 2.19 ± 1.44 | 4.28 ± 3.25 | 0.02* |
UPDRS-III off | 33.08 ± 14.00 | 34.08 ± 13.76 | 33.09 ± 12.68 | 0.79 |
PSPRS score | 38.97 ± 14.00 | 40.32 ± 13.94 | 37.00 ± 13.66 | 0.40 |
PSPRS-history | 7.26 ± 3.82 | 7.47 ± 3.89 | 6.81 ± 3.86 | 0.55 |
PSPRS-mentation | 2.50 ± 2.68 | 2.57 ± 2.53 | 1.81 ± 2.34 | 0.29 |
PSPRS-bulbar | 2.52 ± 1.69 | 2.79 ± 1.62 | 2.00 ± 1.54 | 0.08 |
PSPRS-ocular | 9.93 ± 2.99 | 10.08 ± 3.07 | 9.63 ± 2.60 | 0.59 |
PSPRS-limb | 5.07 ± 2.51 | 5.09 ± 2.48 | 5.69 ± 2.41 | 0.40 |
PSPRS-gait | 11.40 ± 4.56 | 12.11 ± 4.18 | 10.31 ± 5.19 | 0.15 |
PSP staging | 3.13 ± 0.94 | 3.24 ± 0.91 | 2.81 ± 0.98 | 0.10 |
MoCA | 19.00 ± 6.60 | 19.05 ± 5.81 | 20.50 ± 6.04 | 0.41 |
HAM-A | 5.41 ± 6.30 | 4.96 ± 6.23 | 6.19 ± 5.86 | 0.48 |
HAM D | 7.47 ± 5.90 | 7.04 ± 5.15 | 6.81 ± 5.76 | 0.88 |
PDSS | 128.49 ± 18.10 | 130.36 ± 17.31 | 124.75 ± 17.59 | 0.26 |
NMSS | 47.08 ± 32.4 | 48.89 ± 35.88 | 37.31 ± 22.29 | 0.22 |
Caregiver burden | 21.88 ± 12.5 | 21.26 ± 13.02 | 22.89 ± 9.51 | 0.73 |
significant difference between patients with PSP-RS and those with PSP-P.
HAM-A: Hamilton Anxiety Rating Scale, HAM-D: Hamilton Depression Rating Scale, M: men, MoCA: Montreal Cognitive Assessment, NMSS: Non-Motor Symptom Scale, PDSS: Parkinson’s Disease Sleep Scale, PSP: progressive supranuclear palsy, PSPRS: Progressive Supranuclear Palsy Rating Scale, PSP-P: PSP-parkinsonism, PSP-RS: PSP-Richardson syndrome, UPDRS: Unified Parkinson’s Disease Rating Scale, W: women.