Figure 4.

Kaplan–Meier curves with time-dependent ROC (+95% CI) over 120 months and AUC at 60 months showing the survival and predictive value according to the extended version of the proposed clinical risk score with 4 factors (World Health Organization (WHO) grading G1 vs. G2/G3, presence of metastases, CRP ≥0.2 mg/dL, and primary tumor-size ≥3 cm) for the whole cohort (n = 358; grading missing = 6) (A) Overall survival (B) Disease-specific survival (death due to panNEN progression) (C) Recurrence-free survival. AUC = Area under the curve; CRS = Clinical risk score; ROC = receiver operating characteristics; t60 = timepoint 60 months; timeROC = time-dependent receiver operating characteristics