Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 29;12(5):1117. doi: 10.3390/cancers12051117

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Celecoxib is not a Pgp inhibitor and does not increase the toxicity of DOX. (a) In contrast to verapamil (blue), a known Pgp inhibitor, 16–160 µM CEL (green) does not inhibit the function of Pgp. (b,c) CEL does not show synergistic toxicity with DOX in P388 (b) or in CLBL-1 (c) cells. (d,e) Effect of CEL treatment on MDR in Pgp-expressing P388/ADR (d) and CLBL-1 D (e). CEL treatment resulted in a more pronounced reduction of MAF in Pgp-expressing P388/ADR (d) and CLBL-1 D (e) cells than drug holiday (DH).