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. 2020 May 18;13(5):99. doi: 10.3390/ph13050099

Figure 5.

Figure 5

Effects of local administration of 100 μM RJR2403 (RJR: selective α4β2-nAChR agonist: closed circles) into the RTN on pre-AMPA-evoked (panel A) and post-AMPA-evoked (panel B) l-glutamate release (before and after hemichannel activation induced by perfusion with FCHK-MRS into the MDTN for 20 min) in the OFC of S286L-TG. Ordinates indicate mean extracellular l-glutamate level (μM) (N = 6), and abscissas indicate time after AMPA-evoked stimulations (min). Closed bars indicate the perfusion with RJR2403 into the RTN. Gray bars indicate the perfusion with 100 μM AMPA into the MDTN. (Panel C) indicates the AUC value of the extracellular l-glutamate level (nmol) before (basal extracellular l-glutamate level) and after AMPA-evoked stimulation (from 20 to 180 min) of panels (A,B). Opened columns indicate the AUC values of basal extracellular levels of l-glutamate in panel (A,B). * p < 0.05; relative to control by MANOVA with Tukey’s post hoc test. The control data were the same data in Figure 3.