Table 2.

Redox status in the blood of the Urinary bladder cancer patients and the controls.

Redox Parameter	Urinary Bladder Cancer N = 122	Control N = 115	Beta (ß) Coefficient	p-Value 1
Se 2	67.52 ± 16.43	74.67 ± 16.98	−0.204	0.004
NRF2	8.540 ± 0.337	8.448 ± 0.257	0.142	0.044
KEAP1	5.466 ± 0.336	5.848 ± 0.410	−0.460	0.000
MAFG	7.970 ± 0.281	7.983 ± 0.261	−0.047	0.511
ABCC4	5.932 ± 0.744	5.973 ± 0.473	−0.056	0.431
GCLC	6.427 ± 0.398	6.307 ± 0.318	0.153	0.027
GCLM	7.834 ± 0.346	7.890 ± 0.224	−0.122	0.089
GSR	7.189 ± 0.371	7.280 ± 0.524	−0.184	0.009
GSTP1	10.390 ± 0.260	10.420 ± 0.200	−0.013	0.851
HMOX1	8.649 ± 0.357	8.820 ± 0.256	−0.199	0.003
MMP9	8.475 ± 0.824	8.201 ± 0.606	0.164	0.021
NQO1	5.461 ± 0.509	5.620 ± 0.486	−0.160	0.023
OGG1	3.144 ± 0.479	3.541 ± 0.692	−0.316	0.000
PRDX1	9.491 ± 0.226	9.534 ± 0.158	−0.070	0.309
SOD1	9.075 ± 0.306	9.064 ± 0.239	0.010	0.884
SOD2	11.00 ± 0.53	10.91 ± 0.429	0.134	0.060
SRXN1	7.944 ± 0.492	7.874 ± 0.534	0.063	0.379
UGT1A6	3.393 ± 0.861	3.572 ± 1.051	−0.036	0.620
GPX1	11.82 ± 0.55	11.72 ± 0.42	0.092	0.182
SELT	7.371 ± 0.248	7.363 ± 0.314	0.091	0.200
SEP15	9.108 ± 0.161	9.090 ± 0.142	0.137	0.047
SEPW1	6.058 ± 0.335	6.480 ± 0.439	−0.497	0.000
TRXR1	5.151 ± 0.482	5.170 ± 0.344	−0.097	0.170
DNMT1	6.696 ± 0.314	6.869 ± 0.260	−0.320	0.000
DNMT3A	6.316 ± 0.403	6.408 ± 0.306	−0.187	0.009
SIRT1	6.191 ± 0.274	6.262 ± 0.261	−0.139	0.050
Tail DNA (%) 3	6.902 ± 2.741	4.694 ± 1.705	0.446	0.000
Ox Tail DNA (%) 4	10.810 ± 3.350	7.195 ± 2.001	0.536	0.000

¹ The p-values were calculated by a linear regression on Box-Cox transformed values adjusted by age, gender, BMI, and smoking and alcohol habits; separate statistical models for each gene were used; ² plasma selenium level (µg/L); values in bold are significant after Bonferroni correction for 25 genes, p-value < 0.002; NQO1—1 missing patient; UGT1A6—6 missing patients and 113 controls; OGG1—1 missing patient; the percentages of DNA damage ³ and oxidative DNA damage ⁴.