Figure 1.

Lysine-specific histone demethylase 3 (KDM3) demethylase protein structures. The KDM3A–D protein architecture consists of a common C₂HC₄-type zinc-finger-like motif (red color) LXXLL motif (blue color) and one Jumonji C domain (JmjC) domain (orange color) in the C-terminal catalytic site. KDM3B contains a serine-rich region (yellow color). KDM3D also possesses a nuclear matrix targeting signal (NMTS; green color) a nuclear localization signal (NLS; gray color) and two ϕXXϕϕ motifs (purple color) that serve as thyroid hormone receptor interaction domains.