Figure 2.

Schematic representation of the major functions of KDM3 in humans. The KDM3 family consists of four proteins: KDM3A (orange) KDM3B (blue) KDM3C (red) and KDM3D (green). These proteins regulate gene expression and chromatin dynamics by demethylating H3K9me1/2. KDM3 family proteins normally function in energy metabolism, homeostasis, obesity, sex determination, hematopoiesis, hormone nuclear receptor signaling, spermatogenesis, and cell signaling pathways. However, dysregulation in KDM3 expression or function promotes skin and hair defects and tumorigenic processes such as cell survival under hypoxia, malfunction of tumor suppressor genes, induction of oncogenes, development of chemoresistance, and metastasis in cancer patients.