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. 2020 May 20;10(5):792. doi: 10.3390/biom10050792

Figure 7.

Figure 7

Involvement of CB1 and CB2 cannabinoid receptors and β-adrenergic receptors in the terpineol antidepressant-like effect in the tail suspension test (TST: A,B) and splash test (ST: C,D). Mice were treated with a selective CB1 cannabinoid receptor antagonist/inverse agonist (AM281: 1 mg/kg, i.p.—left panel), a potent and selective inverse agonist for the CB2 cannabinoid receptor (AM630: 1 mg/kg, i.p.—left panel) or with the β-adrenoceptor antagonist propranolol (2 mg/kg, i.p.—right panel). After 30 min the animals received terpineol (200 mg/kg, p.o.), and 1 h later they were treated with LPS (0.5 mg/kg, i.p.). After 24 h of LPS administration, the behavioral analyses were performed. The data are presented as the mean ± SEM of six to eight mice/group, with black dot showing individual mice. Differences between groups are indicated: *p < 0.05 and **p < 0.01 compared to the LPS group; # p < 0.05 and ## p < 0.01 compared to the naïve group; ΔΔp < 0.01 compared to the terpineol group.