Table 3.
The effect of the treatment on the pathology score and the goblet and epithelial cell % in the colonic tissue (least square means with their standard errors).
| Treatment | SEM | Contrasts | ||||||
|---|---|---|---|---|---|---|---|---|
| Control | Basal DSS | Laminarin DSS | Chitosan DSS | 1 | 2 | 3 | ||
| Pathology score | 1.0 | 2.0 | 1.7 | 1.9 | 0.330 | * | NS | NS |
| Goblet cell % | 14.9 | 27.02 | 23.12 | 22.54 | 2.72 | ** | NS | NS |
| Epithelial cell % | 85.1 | 72.99 | 76.88 | 77.46 | 2.72 | ** | NS | NS |
The pathology scores range from 1–5 as follows: 1 = normal, non-ulcerating epithelium with a reduced lamina proprial cell infiltration; 2 = normal with a lamina proprial cell infiltration within the normal spectrum; 3 = colonic samples with focal (single) regions of ulceration; 4 = samples with multiple foci of ulceration interspersed between regions of normal colon and 5 = samples with diffuse ulceration. Contrasts: (1) Control vs. Basal DSS; (2) Basal DSS vs. Laminarin DSS; (3) Basal DSS vs. Chitosan DSS; NS, non-significant; * p < 0.05; ** p < 0.01.