Table 1.
Characteristics of included studies
| Ref. | Yr | Nationality | Osteoarthritis type |
Sample size (female / male) |
Age (mean) |
Study single nucleotide polymorphisms | Genotype method |
Newcastle-Ottawa Scale |
Hardy-Weinberg equilibrium | ||||
| Case | Control | Case | Control | I | II | III | |||||||
| Zhang et al[20] | 2019 | China | Knee | 122 (90/32) | 124 (88/36) | 66 | 66 | rs2275913 | PCR | 3 | 0 | 3 | Yes |
| rs763780 | PCR | 3 | 0 | 3 | Yes | ||||||||
| Zhang et al[20] | 2019 | China | Knee | 76 (52/24) | 68 (49/19) | 62 | 61 | rs2275913 | PCR | 3 | 0 | 3 | Yes |
| rs763780 | PCR | 3 | 0 | 3 | Yes | ||||||||
| Jiang et al[21] | 2019 | China | NA | 410 (271/139) | 507 (348/159) | 57.35 | 57.88 | rs2275913 | PCR-RFLP | 3 | 1 | 3 | Yes |
| rs763780 | PCR-RFLP | 3 | 1 | 3 | Yes | ||||||||
| Bai et al[22] | 2019 | China | Knee | 594 (393/201) | 576 (402/174) | 59.5 | 58.3 | rs2275913 | PCR | 3 | 1 | 3 | Yes |
| rs763780 | PCR | 3 | 1 | 3 | Yes | ||||||||
| Bafrani et al[12] | 2019 | Iran | Knee | 127 (69/58) | 127 (73/54) | 68.06 | 66.84 | rs2275913 | PCR-RFLP | 3 | 1 | 3 | Yes |
| rs763780 | PCR-RFLP | 3 | 1 | 3 | Yes | ||||||||
| rs2397084 | PCR-RFLP | 3 | 1 | 3 | Yes | ||||||||
| Vrgoc et al[23] | 2018 | Croatia | Hip | 260 (175/85) | 597 (152/445) | 67.82 | 42.64 | rs2275913 | TaqMan | 3 | 1 | 3 | Yes |
| rs763780 | TaqMan | 3 | 1 | 3 | Yes | ||||||||
| rs1889570 | TaqMan | 3 | 1 | 3 | Yes | ||||||||
| Vrgoc et al[23] | 2018 | Croatia | Knee | 240 (174/66) | 597 (152/445) | 69.74 | 42.64 | rs2275913 | TaqMan | 3 | 1 | 3 | Yes |
| rs763780 | TaqMan | 3 | 1 | 3 | Yes | ||||||||
| rs1889570 | TaqMan | 3 | 1 | 3 | Yes | ||||||||
| Han et al[24] | 2014 | SouthKorea | Knee | 302 (245/57) | 300 (136/164) | 60 | 51 | rs2275913 | PCR-SSCP | 3 | 0 | 3 | No |
| rs763780 | PCR-SSCP | 3 | 0 | 3 | No | ||||||||
Newcastle-Ottawa Scale is available from http://www.ohri.ca/programs/clinical epidemiology/oxford.asp. I: Selection; II: Comparability; III: Exposure; NA: Not available; PCR: Polymerase chain reaction; RFLP: Restriction fragment length polymorphism; SSCP: Single-strand conformation polymorphism.