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. 2020 May 23;13(5):103. doi: 10.3390/ph13050103

Figure 1.

Figure 1

Schematic illustration of degron-based technologies for protein depletion in the presence of a defined ligand. (A) dTAG: a chemical degrader such as dTAG-13 and -47 binds a FKBP12(F36V)-fused POI and CRL4–CRBN, resulting in rapid degradation of the FKBP12(F36V)-fused POI via USP. (B) HaloPROTAC: a chemical degrader such as HaloPROTAC3 binds a HaloTag-fused POI, resulting in rapid degradation of the HaloPROTAC-fused POI via USP. (C) Auxin-inducible degron (AID): IAA or NAA binds OsTIR1, a component of SCF–OsTIR1. Subsequently, an mAID-fused POI is recognized for rapid degradation via UPS.