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. 2020 May 21;12(5):1304. doi: 10.3390/cancers12051304

Figure 4.

Figure 4

In Vitro drug response. Cell viability of six-day PDX tumor spheroids BL0293 (A) and BL0808 (B) treated with 10 μM cisplatin, gemcitabine, and combination thereof for 24, 48, and 72 h. Data displayed as cell viability mean ± SD, referring to two experimental replicates with three technical replicates each (n = 6). T-student statistical method with * p < 0.01 vs. control. In Vivo drug response: variation of tumor volume for PDX mice BL0808 (C). Mice were randomly assigned to the treatment groups and treated with cisplatin at 2 mg/kg (intravenous injection every seven days at 3 doses), gemcitabine at 150 mg/kg (intraperitoneal injection every seven days at 4 doses), or their combination. Data displayed as tumor volume mean ± SEM of a group with six animals (n = 6).