Figure 5.

Nelfinavir potentiates activity of proteasome inhibitors. OPM-2 and RPMI8226 MM cell lines were co-treated with 5 nM BTZ or 5 nM CFZ and 10 μM or 20 μM nelfinavir for 24 h. Chymotrypsin-like activity of the proteasome was measured in cell lysates at 37 °C. To assess the level of significance, Dunnett’s multiple comparison tests were used, p values are indicated (n = 3).