Figure 2.

Embryos and placentae weight. On day E18.5, 6 days after injection of either DXR or saline, embryos and placentae were removed from the uterus (n = 52, from 5 DXR-treated pregnant mice and n = 61, from 5 control pregnant mice). Each embryo (A) and its placenta (B) were weighed separately (gram); fetal to placenta weight ratio index (FPI) was calculated (C). Data are expressed as mean ± SEM. Control and DXR groups presented normal distribution of their litter size, embryos’ and placentae’ weights, and the FPI values, by the Kolmogorov–Smirnov test. The litter size of the two groups is not statistically different from one another or from the average litter size of ICR (Institute of Cancer Research) females (reported by Envigo). Individual comparisons were made using a Student’s t-test. (*) P value of 0.05 was considered statistically significant.