Table 1.
Number of positively enriched gene sets at different significance levels for each age group in each cohort from preranked gene set enrichment analysis (GSEA).
| Age Group | Dataset | Number of Features | Number of Positive Gene Sets | Nominal p < 0.01 | FDR q < 0.25 | FDR q < 0.05 | Number of Overlaps at FDR q < 0.05 |
|---|---|---|---|---|---|---|---|
| Young | TCGA-BRCA | 19,879 | 1370 | 126 | 135 | 33 | 1 |
| Young | METABRIC | 24,360 | 3765 | 246 | 204 | 30 | |
| Old | TCGA-BRCA | 20,201 | 2801 | 42 | 3 | 0 | 1 |
| Old | METABRIC | 24,360 | 3793 | 95 | 8 | 1 |
1 “Number of features” denotes the number of genes in the ranked gene list used as input for the analyses.