Table 1.
Characteristics of individuals with monogenic hypercholesterolemia and polygenic hypercholesterolemia.
| Parameter | Polygenic Hypercholesterolemia n = 65 | Monogenic Hypercholesterolemia n = 47 | p Value |
|---|---|---|---|
| Age, years * | 54.37 ± 12.54 | 50.57 ± 13.49 | 0.134 |
| Female | 42 (64.62%) | 28 (59.57%) | 0.586 |
| Prevention Primary | 48 (73.85%) | 31 (65.96%) | 0.366 |
| Prevention Secondary | 17 (26.15%) | 16 (34.04%) | 0.366 |
| CVD | 15 (23.08%) | 15 (31.91%) | 0.297 |
| CAD | 13 (20.00%) | 13 (27.66%) | 0.343 |
| CAD age, years * | 49.45 ± 10.96 | 47.30 ± 3.56 | 0.548 |
| MI | 21 (32.31%) | 8 (17.02%) | 0.311 |
| MI age, years * | 48.70 ± 11.25 | 47.38 ± 5.40 | 0.748 |
| PCI | 7 (10.77%) | 9 (19.15%) | 0.211 |
| PCI age, years * | 46.57 ± 12.16 | 46.78 ± 3.35 | 0.966 |
| CABG | 4 (6.15%) | 3 (6.38%) | 0.961 |
| CABG age, years * | 48.00 ± 5.20 | 51.5 ± 0.71 | 0.364 |
| Stroke/TIA | 3 (4.62%) | 2 (4.26%) | 0.748 |
| Smoking | 11 (16.92%) | 7 (14.89%) | 0.783 |
| HA | 22 (33.85%) | 23 (48.94%) | 0.169 |
| DM | 6 (9.23%) | 2 (4.26%) | 0.303 |
| BMI (kg/m2)* | 26.57 ± 4.11 | 26.24 ± 4.62 | 0.720 |
| FH Definite Probable Possible |
2 (3.08%) 29 (44.62%) 34 (52.31%) |
24 (51.06%) 21 (44.68%) 2 (4.26%) |
<0.001 0.995 <0.001 |
| Family history of hypercholesterolemia in adults aged >18 years defined as LDL-C > 4.9 mmol/L (190 mg/dL) | 22 (33.85%) | 39 (82.98%) | <0.001 |
| Family history of hypercholesterolemia in children defined as LDL-C >4.0 mmol/L (155 mg/dL) | 6 (9.23%) | 12 (25.53%) | 0.021 |
| Family history of premature CAD (in men below age 55, in women below 60 years) | 49 (75.38%) | 35 (74.47%) | 0.912 |
| Corneal arcus <45 y | 1 (1.54%) | 5 (10.64%) | 0.046 |
| Tendinous xanthomata | 0 | 1 (2.13%) | 0.420 |
Data are presented as * mean ± standard deviation or as number (percentage). Abbreviations: BMI—Body mass index, CAD—coronary artery disease, CABG—Coronary artery bypass grafting, CVD—Cardiovascular disease, DM—diabetes, FH—familial hypercholesterolemia, HA—arterial hypertension, MI—myocardial infarction, PCI—percutaneous intervention, TIA—transient ischemic attack.