Table 3.

Low density lipoprotein cholesterol (LDL-C) reduction and LDL-C goal achievement in monogenic and polygenic hypercholesterolemia.

A. LDL-C reduction (%)
Inverse Probability Weighted Regression Adjustment (IPWRA)
Group	Mean,% *	p value	95% CI
			lower	upper
Monogenic	45.9	<0.001	42.0	49.8
Polygenic	55.4		52.7	58.1
Ancova
Group	Mean,% *	p value	95% CI
			lower	upper
Monogenic	41.5	<0.001	35.4	47.6
Polygenic	51.6		46.6	56.6
Linear Regression Model
Variable	F(3,107) = 8.23 p < 0.001
	Coefficient	p value	95% CI
			lower	upper
Constant	27.41	<0.001	15.61	39.20
Monogenic/Polygenic	−10.13	<0.001	−15.72	−4.54
LDL baseline	0.11	<0.001	0.06	0.16
Diabetes melitus	−9.38	0.052	−18.84	0.08
B. LDL-C Goal Achievement
Inverse Probability Weighted Regression Adjustment (IPWRA)
Group	Probability of goal achievement	p value	95% CI
			lower	upper
Monogenic	0.075	0.004	0.008	0.142
Polygenic	0.245		0.151	0.339
Risk Ratio Polygenic vs. Monogenic = 3.28			1.23	8.72
Logistic Regression
Variable	LR Chi2 (2) = 16.90 p < 0.001
	Odds ratio	p value	95% CI
			lower	upper
Constant	0.625	0.103	0.355	1.100
Monogenic/Polygenic	0.281	0.023	0.094	0.840
CVD	0.087	0.020	0.011	0.686

Data are presented as * mean and 95% CI or numbers and 95% CI. Abbreviations: see Table 1 and Table 2.