Figure 3.

FN regulation of genes involved in DNA damage repair. TYK-nu cells were seeded onto a HA and FN matrix for 24 h; then, total RNA was extracted from cell lysates, and real-time qPCR was performed to evaluate the gene expression of MSH2 (A), OGG1 (B), PMS2 (C), ERCC1 (D) and XRCC3 (E). MSH2 and XRCC3 expression were significantly increased by FN’s influence, whereas HA seemed to downregulate their expression. TATA-box binding protein (TBP) was used as a housekeeping gene to normalize gene expression results. * p < 0.05.