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. 2020 May 12;12(5):1210. doi: 10.3390/cancers12051210

Figure 6.

Figure 6

Assessment of combinatorial treatment’s effect (Ad-fosARE and PTX) on viral replication and cell lysis activity. (a) Cancer (HeLa and A549) cells and normal (BJ) cells were infected with Ad-fosARE at an MOI of 10 ifu/cell and 4 nM PTX. Virus production was determined 48 h after through Hexon staining. Each titer (ifu/mL) is shown on the graph. Data are shown above as the mean ± standard deviation of three independent experiments. (b) Cell lysis activities of combination treatment were measured using the XTT assay. As mentioned above, cancer and normal cells were infected with the virus at an MOI of 10 ifu/cell and cell viabilities were estimated 1, 3, 5, and 7 days after infection. (c) Prior mentioned cancer and normal cells were subjected to staining with Coomassie brilliant blue 7 days after infection to observe cytopathic effects. Living cells stained blue. (* indicates p < 0.05, ** indicate p < 0.01).