Skip to main content
. 2020 May 4;10(5):709. doi: 10.3390/biom10050709

Figure 8.

Figure 8

Effect of pterostilbene on RAGE, PI3K, Akt, and MDR1 expression in RAGE knockdown MIA PaCa-2 GEMR cells. Cells were transfected with 25 nM control siRNA or siRAGE for 24 h followed by 75 μM pterostilbene treatment for another 72 h. (A) The expression levels of MDR1, PI3K, Akt, and RAGE protein in RAGE knockdown MIA PaCa-2 GEMR cells were analyzed by western blotting. The relative expression levels of (B) RAGE, (C) PI3K, (D) p-PI3K, (E) Akt, (F) p-Akt, and (G) MDR1 in RAGE knockdown MIA PaCa-2 GEMR cells are expressed as the mean ± SD (n = 3). p values were considered statistically significant when *p < 0.05, **p < 0.01, and ***p < 0.001 compared with untreated control. †p < 0.05 and ‡p < 0.05 compared with pterostilbene-treated siRAGE cells.