Table 3.
Examples of deregulation of circular RNAs (circRNAs) in HCC.
| Clinical Samples Used | ncRNA | Expression Level | Function | References |
|---|---|---|---|---|
| 289 HCC samples and paired adjacent liver tissues | circMTO1 | Down-regulated | Acts as a sponge for oncogenic miR-9 to promote p21 expression | [133] |
| 208 pairs of HCC and adjacent normal liver | cSMARCA5 | Down-regulated | Sponges miR-17-3p and miR-181b-5p which target TIMP3 | [134] |
| 75 HCC tissues with metastasis or no metastasis | circ-10720 | Up-regulated | Sponges several miRNAs targeting vimentin and induces EMT and metastasis | [135] |
| 100 paired HCC tissues and adjacent normal tissues | circMAT2B | Up-regulated | Sponges miR-338-3p thus upregulating PKM2 and glycolysis | [136] |
| 15 metastatic and 15 non-metastatic HCC | circASAP1 | Up-regulated | Sponges miR-326 and miR-532-5p to induce MAPK1 and CSF-1 | [137] |
| 100 paired HCC tissues and adjacent normal tissues | circRHOT1 | Up-regulated | Recruits TIP60 to NR2F6 promoter to increase transcription | [138] |