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. 2020 May 13;12(5):1221. doi: 10.3390/cancers12051221

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Survival analysis of the cancer genome atlas (TCGA) liver hepatocellular carcinoma (LIHC) patients. Kaplan-Meier curves of (a) PFI (p = 0.003), (b) DFI (p = 0.013), (c) DSS (p = 0.026), and (d) OS (p = 0.005) in CYT-high vs. -low patients. Survival curves of OS were further stratified by four major T cell exhaustion markers using the median value of each expression. (e) PD-1 (p = 0.01), (f) CTLA4 (p = 0.0001), (g) PD-L1 (p = 0.024), and (h) LAG3 (p = 0.018). Log-rank test was used to test group differences in survival analyses. CYT, cytolytic activity score; PFI, progression-free interval; DFI, disease-free interval; DSS, disease-specific survival; OS, overall survival; PD-1, program death-1; CTLA4, cytotoxic T-lymphocyte-associated protein 4; PD-L1, program death-ligand 1; and LAG3, lymphocyte-activation gene 3.