Table 3.
Univariate and multivariate analysis for the OS.
| Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| Age | 1.03 | 1.005–1.049 | 0.016 | 1.03 | 1.006–1.051 | 0.013 |
| Gender | 0.81 | 0.483–1.364 | 0.432 | |||
| Stage (II vs. I) | 1.83 | 0.948–3.538 | 0.072 | 2.03 | 1.046–3.948 | 0.036 |
| Stage (III vs. I) | 2.46 | 1.340–4.527 | 0.004 | 2.74 | 1.488–5.049 | 0.001 |
| Stage (IV vs. I) | 8.42 | 2.484–28.543 | <0.001 | 12.58 | 3.531–44.853 | <0.001 |
| Adjacent hepatic tissue inflammation extent type (Mild vs. None) |
1.24 | 0.717–2.129 | 0.446 | |||
| Adjacent hepatic tissue inflammation extent type (Severe vs. None) |
0.98 | 0.343–2.778 | 0.964 | |||
| Virus status (Alcohol consumption vs. None) |
0.58 | 0.291–1.175 | 0.132 | |||
| Virus status (Hepatitis B vs. None) |
0.43 | 0.209–0.891 | 0.023 | |||
| Virus status (Hepatitis C vs. None) |
1.05 | 0.424–2.602 | 0.916 | |||
| Virus status (Others vs. None) | 0.94 | 0.400–2.210 | 0.887 | |||
| TIL (positive vs. negative) | 1.11 | 0.662–1.864 | 0.692 | |||
| CYT (high vs. low) | 0.55 | 0.326–0.921 | 0.023 | 0.47 | 0.275–0.819 | 0.007 |
OS, overall survival; HR, hazard ratio; CI, confidence interval; and CYT, cytolytic activity.