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. 2020 May 2;12(5):1146. doi: 10.3390/cancers12051146

Figure 5.

Figure 5

Copy number alteration is closely correlated with dysregulated expression of the gene signature. (A) Most genes (10/12) involved in the gene signature were dysregulated in 19 paired BCa and adjacent normal tissues from The Cancer Genome Atlas (TCGA). (B) An Oncoprint was plotted to visualize the genomic alterations including mutation and copy number alteration of the gene signature in 413 TCGA BCa samples. (C) Overview of relationships between copy number and mRNA expression is plotted. Bubble size represents Pearson correlation coefficient, and color presents the significance. Two representative genes RCE1 and CEP72 with r > 0.5 are shown in detail. (D) Copy numbers of RCE1 and CEP72 were frequently amplified in most BCa cell lines, and highly positive correlation between copy number and mRNA expression of RCE1 (r = 0.7196, p = 0.0002) and CEP72 (r = 0.6728, p = 0.0006) was observed in 22 BCa cell lines. * p < 0.01; N.S., no significance.