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. 2020 May 16;12(5):1260. doi: 10.3390/cancers12051260

Figure 11.

Figure 11

MMP3-knockout resulted in necrotic cell death in tumoroids. Tumoroids were cultured in the ULA-based 3D culture system with a stemness-enhancing medium for 8 days. (A,B) Hematoxylin and eosin (H&E) staining of (A) LuM1- and (B) MMP3-KO tumoroids. Necrotic areas were enclosed with black color, while the total tumoroids area was enclosed with yellow color. Scale bars, 50 µm. (C) The percentage of the necrotic areas in both tumoroids.