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MMP3 enriched-EVs and CM rescue the proliferation of MMP3-KO tumoroids. LuM1-tumoroids or MMP3-KO tumoroids were treated with PBS, LuM1-CM, or LuM1-EVs for 24 h, and then Ki-67 was immunostained. (A) Ki-67 immunostaining (brown) in the LuM1 and MMP3-KO tumoroids. Scale bars; 100 µm (in low magnification images) and 10 µm (in high magnification images). (B) Ki-67 labeling index (%). n = 6, ** p < 0.01, *** p < 0.001; ns, not significant. Experiments were repeated twice.
