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. 2020 May 21;12(5):1307. doi: 10.3390/cancers12051307

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Characterization of CAF subtypes in 4T1 breast cancer. (A) Cell clusters from 10x Genomics scRNA-seq analysis visualized by UMAP. Colors indicate various CAF subtypes. (B) Feature plots showing the expression of commonly used CAF markers in various CAF subtypes. Legend shows a color gradient of normalized expression. (C) Markers of various CAF subtypes that were used to denote each subtype. (D) Heatmap showing a subset of genes differentially expressed between the 6 CAF subtypes. (E) Monocle pseudospace trajectory colored based on CAF clusters in (A). (F) Expression of CAF markers on a pseudotime scale (colored based on CAF clusters in (A)).