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. 2020 May 21;12(5):1307. doi: 10.3390/cancers12051307

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Characterization of CAF subtypes in murine PDAC. (A) UMAP plot showing various CAF subtypes identified in PDAC tumors from KPC mice. (B) Expression of commonly used CAF markers in KPC-derived PDAC CAFs. (C) Dot plot showing the expression of selected markers of Ly6c1^high CAFs (iCAFs) and α-SMA^high CAFs (myCAFs) in KPC-derived PDAC CAFs. Dot size represents the fraction of cells expressing a specific marker in a particular cluster and intensity of color indicates the average expression in that cluster. (D) Violin plots showing the expression of Cd74^high CAF (apCAFs) markers in KPC-derived CAFs (cluster identities on X-axis). (E) CAF subtypes identified in subcutaneous mT3 tumors. (F) Expression of commonly used CAF markers in mT3 tumor-derived CAFs. (G) Dot plot showing the expression of selected iCAF and myCAF markers in mT3-derived CAFs.