Table 1.
IC50 values of L5, L6, and L7 metal complexes and Cisplatin, expressed in μM. The means ± standard deviations are shown.
| IC50 (µM) | ||||||
|---|---|---|---|---|---|---|
| Compounds | MCF-7 | MDA-MB-231 | HeLa | ISHIKAWA | MCF-10A | Hek-293 |
| L5 | >200 | >200 | >200 | >200 | >200 | >200 |
| AgL5 | >200 | >200 | >200 | >200 | >200 | >200 |
| AuL5 | 18.2 ± 0.5 | 31.7 ± 0.8 | 44.5 ± 0.9 | 54.9 ± 1.0 | >200 | >200 |
| L6 | >200 | >200 | >200 | >200 | >200 | >200 |
| AgL6 | 29.7 ± 0.3 | 57.9 ± 0.5 | 47.7 ± 0.4 | 26.7 ± 0.5 | 143.4 ± 0.8 | >200 |
| AuL6 | 9.38 ± 0.2 | 53.7 ± 0.7 | 98.6 ± 1.2 | 12.6 ± 0.3 | 158.8 ± 1.0 | >200 |
| L7 | >200 | >200 | >200 | >200 | >200 | >200 |
| AgL7 | 10.5 ± 0.8 | 3.22 ± 1.2 | 9.76 ± 0.6 | 6.55 ± 0.9 | >200 | >200 |
| AuL7 | 5.18 ± 0.4 | 2.1 ± 0.7 | 31.9 ± 0.5 | 29.9 ± 0.9 | >200 | 65.0 ± 0.7 |
|
AuL7 + Quercetin (4 h) |
- | - | - | - | - | 96.9 ± 1.1 |
| Cis-platin | 35.8 ± 1.3 | 28.7 ± 1.0 | 15.7 ± 1.1 | 15.1 ± 0.8 | 81.3 ± 1.2 | 16.8 ± 0.4 |