Table 2.

Binding Energies and Binding constants for each compound tested in silico towards human topoisomerases I and II and tubulin.

Compounds	Tubulin		Topoisomerase I		Topoisomerase II
	Eb (kcal/mol)	Ki (μM)	Eb (kcal/mol)	Ki (μM)	Eb (kcal/mol)	Ki (μM)
AuL4	−7.4	3.78	−5.83	53.0	−6.39	20.86
AgL5	−7.66	2.43	−7.44	3.51	−7.72	2.21
AuL5	−8.45	0.6629	−7.55	2.92	−7.49	3.03
AgL6	−7.73	2.17	−7.73	2.17	−6.44	18.91
AuL6	−6.76	8.26	−8.9	0.3219	−7.84	4.16
AgL7	−13.27	1.3 × 10−6	−9.18	0.1853	−10.06	0.0423
AuL7	−11.3	0.0052	−8.42	0.6694	−6.84	9.64